The FACT Complex Promotes Avian Leukosis Virus DNA Integration

Avian Leukosis Virus

Ultrastructural studies of chick embryo cells morphological ly altered by strain MC29 avian leukosis virus revealed marked and characteristic differences from normal cells and cells al tered by infection with other avian tumor viruses. Such differ ences were manifest in part in the cytoplasm by high content of free ribosomes, poorly developed rough endoplasmic reticu lum, frequent fat droplets,...

Avian lymphoid leukosis: Virus-like particles in kidney Cells

Selection for avian leukosis virus integration sites determines the clonal progression of B-cell lymphomas

Avian leukosis virus (ALV) is a simple retrovirus that causes a wide range of tumors in chickens, the most common of which are B-cell lymphomas. The viral genome integrates into the host genome and uses its strong promoter and enhancer sequences to alter the expression of nearby genes, frequently inducing tumors. In this study, we compare the preferences for ALV integration sites in cultured ce...

MicroRNA-23b Promotes Avian Leukosis Virus Subgroup J (ALV-J) Replication by Targeting IRF1

Avian leukosis virus subgroup J (ALV-J) can cause several different leukemia-like proliferative diseases in the hemopoietic system of chickens. Here, we investigated the transcriptome profiles and miRNA expression profiles of ALV-J-infected and uninfected chicken spleens to identify the genes and miRNAs related to ALV-J invasion. In total, 252 genes and 167 miRNAs were differentially expressed ...

Fowl Paralysis and Other Forms of the Avian Leukosis Complex

The disease called fowl paralysis, together with several other allied conditions classed together as the avian leukosis complex,^ causes a tremendous loss to the poultry industry. The paralysis form of this disease complex was first recognized in the United States along the eastern coast about 1920. During the last 20 years the avian leukosis complex has spread rapidly until few flocks of chick...